… The histamine sensitization test is a widely used method for … toxicity of pertussis toxin in
acellular pertussis vaccines. … current protocols are difficult to standardize because the test results …

… islet cells; and (3) increased sensitivity to histamine in experimental animals. In terms of its
… a single alternative test method protocol will be appropriate for all aP vaccines. Adoption of …

… leukocytosis, histamine sensitisation, increased insulin production … PT also has been reported
to increase blood brain barrier … after receiving the test materials and protocols due to staff …

… Current application of this test is limited to bulk products, … parameter, which might increase
variability in test outcomes. … To improve sensitivity and reduce variability of this assay, we …

… pertussis vaccines for evaluating improvement of its quality. Histamine-sensitization (HS)
test method based on histamine-… death in mice was prescribed in the WHO guidelines as an …

… safety testing for acellular pertussis vaccines, the “Histamine … WHO guidelines and the
European Pharmacopoeia [4], [5]. … -based test, the cAMP-assay, which assesses the increase of …

… pertussis toxin (PTx) is the Histamine Sensitization test (HIST)… and optimization protocols
of the vaccine production processes. … We use cookies to improve your website experience. To …

… for acellular pertussis-based combination vaccines in order … inter-laboratory variations can
be improved by the use of a … , calibrated in IU, can increase comparability of results among …

… for the histamine sensitisation test (HIST) for acellular pertussis … of new or improved pertussis
vaccines, development and … Protocols for pertussis vaccination vary among countries in …

… The mouse histamine sensitization test (HIST) is the currently … or more HIST protocols may
have to be used when vaccines from … ment to reduce the variability and improve the sensitivity. …